Article
APOE Genotype Differentially Modulates Plasma Lipids in Healthy Older Individuals, with Relevance to Brain Health.
Journal of Alzheimer's disease : JAD - 1 Jan 2019
Wong Matthew Wai Kin, Braidy Nady, Crawford John, Pickford Russell, Song Fei, Mather Karen A, Attia John, Brodaty Henry, Sachdev Perminder, Poljak Anne
Abstract excerpt
Apolipoprotein E (APOE) genotype is an established genetic risk factor for sporadic Alzheimer's disease (AD) but the extent to which APOE genotype influences the plasma lipidome is unknown, even though lipids are potential diagnostic or prognostic biomarkers for AD. We quantified plasma lipids using untargeted liquid chromatography coupled mass spectrometry in a total of 152 non-demented participants aged 65-100...
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