Article
Driver mutation zygosity is a critical factor in predicting clonal hematopoiesis transformation risk.
Blood cancer journal - 15 Jan 2024
Kishtagari Ashwin, Khan M A Wasay, Li Yajing, Vlasschaert Caitlyn, Marneni Naimisha, Silver Alexander J, von Beck Kelly, Spaulding Travis, Stockton Shannon, Snider Christina, Sochacki Andrew, Dorand Dixon, Mack Taralynn M, Ferrell P Brent, Xu Yaomin, Bejan Cosmin A, Savona Michael R, Bick Alexander G
Abstract excerpt
Clonal hematopoiesis (CH) can be caused by either single gene mutations (eg point mutations in JAK2 causing CHIP) or mosaic chromosomal alterations (e.g., loss of heterozygosity at chromosome 9p). CH is associated with a significantly increased risk of hematologic malignancies. However, the absolute rate of transformation on an annualized basis is low. Improved prognostication of transformation risk is urgently...
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