Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis.

doi:10.1038/s41588-023-01555-z

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Article

Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis.

Nature genetics - 1 Dec 2023

Stacey Simon N, Zink Florian, Halldorsson Gisli H, Stefansdottir Lilja, Gudjonsson Sigurjon A, Einarsson Gudmundur, Hjörleifsson Grimur, Eiriksdottir Thjodbjorg, Helgadottir Anna, Björnsdottir Gyda, Thorgeirsson Thorgeir E, Olafsdottir Thorunn A, Jonsdottir Ingileif, Gretarsdottir Solveig, Tragante Vinicius, Magnusson Magnus K, Jonsson Hakon, Gudmundsson Julius, Olafsson Sigurgeir, Holm Hilma, Gudbjartsson Daniel F, Sulem Patrick, Helgason Agnar, Thorsteinsdottir Unnur, Tryggvadottir Laufey, Rafnar Thorunn, Melsted Pall, Ulfarsson Magnus Ö, Vidarsson Brynjar, Thorleifsson Gudmar, Stefansson Kari

Abstract excerpt

Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of 45,510 Icelandic and 130,709 UK Biobank participants combined with a mutational barcode method, we identified 16,306 people with CH. Prevalence approaches 50% in elderly participants. Smoking demonstrates a dosage-dependent impact on risk...

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PMID: 37932435
DOI: 10.1038/s41588-023-01555-z
PMCID: PMC10703693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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