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Article

Influence of the APOE genotype on hepatic stress response: Studies in APOE targeted replacement mice and human liver cells.

Free radical biology & medicine - 1 Jul 2016

Dose Janina, Nebel Almut, Piegholdt Stefanie, Rimbach Gerald, Huebbe Patricia

Abstract excerpt

Apolipoprotein E (APOE) is a multifunctional plasma protein mainly acting in lipid metabolism. Human APOE is polymorphic with three major isoforms (APOE2, APOE3 and APOE4). Up to 75% of the body's APOE is produced by the liver. There is increasing evidence from studies in brain-derived cells that APOE4 affects mitochondrial function and biogenesis as well as stress and inflammatory responses - processes, whose...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27130033
DOI: 10.1016/j.freeradbiomed.2016.04.031

Genes

APOE
BAX
BCL2
CYCS
DDIT3
XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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