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Article

Investigating the effects of PTEN mutations on cGAS-STING pathway in glioblastoma tumours.

Journal of neuro-oncology - 1 Jan 2024

Dogan Eda, Yildirim Zafer, Akalin Taner, Ozgiray Erkin, Akinturk Nevhis, Aktan Cagdas, Solmaz Asli Ece, Biceroglu Huseyin, Caliskan Kadri Emre, Ertan Yesim, Yurtseven Taskin, Kosova Buket, Bozok Vildan

Abstract excerpt

BACKGROUND: PTEN is a tumour suppressor gene and well-known for being frequently mutated in several cancer types. Loss of immunogenicity can also be attributed to PTEN loss, because of its role in establishing the tumour microenvironment. Therefore, this study aimed to represent the link between PTEN and cGAS-STING activity, a key mediator of inflammation, in tumour samples of glioblastoma patients. METHODS:...

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Source

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Identifiers

PMID: 38214828
DOI: 10.1007/s11060-023-04556-4
PMCID: PMC10834568

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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