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Article

PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer.

Nature communications - 26 Aug 2021

Sun Yizhe, Lu Dan, Yin Yue, Song Jia, Liu Yang, Hao Wenyan, Qi Fang, Zhang Guangze, Zhang Xin, Liu Liang, Lin Zhiqiang, Liang Hui, Zhao Xuyang, Jin Yan, Yin Yuxin

Abstract excerpt

PTEN is frequently mutated in human cancers and PTEN mutants promote tumor progression and metastasis. PTEN mutations have been implicated in immune regulation, however, the underlying mechanism is largely unknown. Here, we report that PTENα, the isoform of PTEN, remains active in cancer bearing stop-gained PTEN mutations. Through counteraction of CD8+ T cell-mediated cytotoxicity, PTENα leads to T cell...

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Identifiers

PMID: 34446716
DOI: 10.1038/s41467-021-25417-6
PMCID: PMC8390757

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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