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Article

STING activation increases the efficiency of temozolomide in PTEN harbouring glioblastoma cells

12 Jun 2024

Abstract excerpt

Background/aim: Glioblastoma is one of the most aggressive tumours, resistant to all applied therapy regiments and prone to relapse. Median survival rates are therefore only expressed as months. STING agonists are immunomodulatory molecules that activate type I interferon expression, making them potentially useful in regulating the tumour microenvironment. Since PTEN serves as a critical phosphatase in activating...

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PMID: 39049995
DOI: 10.55730/1300-0144.5828

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