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Article

Is there a causal link between PTEN deficient tumors and immunosuppressive tumor microenvironment?

30 Jan 2020

Abstract excerpt

The PTEN tumor suppressor is the second most commonly inactivated gene across cancer types. While it's role in PI3K/AKT and DNA damage pathways are clear, increasing evidences suggest that PTEN may also promote anti-tumor immunity. PTEN-deficient tumors are characterized by (i) reduced levels of cytotoxic T cells, helper T cells and NK cells, (ii) elevated pro-oncogenic inflammatory cytokines like CCL2 and (iii)...

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PMID: 32000794
DOI: 10.1186/s12967-020-02219-w

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