Article

PTEN and BRCA1 tumor suppressor loss associated tumor immune microenvironment exhibits differential response to therapeutic STING pathway activation in a murine model of ovarian cancer

2022-07-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> High grade serous ovarian carcinoma (HGSC) is the most lethal gynecologic malignancy characterized by chemoresistance and high rates of recurrence. HGSC tumors display a high prevalence of tumor suppressor gene loss. Loss of BRCA1 and PTEN function due to mutations or epigenetic influence have been widely associated with variable clinical outcomes, where tumors with BRCA1...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f762466c-0604-5582-9340-fad63acf5ca9
DOI: 10.1101/2022.06.27.497846

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PTEN and BRCA1 tumor suppressor loss associated tumor immune microenvironment exhibits differential response to therapeutic STING pathway activation in a murine model of ovarian cancerDOI 10.1101/2022.06.27.497846Read

Cancer cell genotype associated tumor immune microenvironment exhibits differential response to therapeutic STING pathway activation in high-grade serous ovarian cancer.Semantic proximity Read

Chemotherapy induces myeloid-driven spatial T-cell exhaustion in ovarian cancerSemantic proximity Read

Integrated immunogenomic analyses of high-grade serous ovarian cancer reveal vulnerability to combination immunotherapySemantic proximity Read

Unraveling Tumor-Immune Heterogeneity in Advanced Ovarian Cancer Uncovers Immunogenic Effect of ChemotherapySemantic proximity Read

Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian CarcinomaSemantic proximity Read

Chemotherapy induced immunogenic cell death alters response to exogenous activation of STING pathway and PD-L1 immune checkpoint blockade in a syngeneic murine model of ovarian cancerSemantic proximity Read

Testicular sex cord–stromal tumors in mice with constitutive activation of PI3K and loss of PtenSemantic proximity Read

Improving PARP inhibitor efficacy in high-grade serous ovarian carcinoma: A focus on the immune systemSemantic proximity Read

Mapping ovarian cancer spatial organization uncovers immune evasion drivers at the genetic, cellular, and tissue levelSemantic proximity Read

Immune microenvironment composition in high-grade serous ovarian cancers based on BRCA mutational statusSemantic proximity Read

Spatial tumor immune microenvironment phenotypes in ovarian cancerSemantic proximity Read

Murine Oviductal High-Grade Serous Carcinomas Mirror the Genomic Alterations, Gene Expression Profiles, and Immune Microenvironment of Their Human CounterpartsSemantic proximity Read