Article

cGAS-STING pathway targeted therapies and their applications in the treatment of high-grade glioma

2022-09-07

Abstract excerpt

Median survival of patients with glioblastoma (GBM) treated with standard of care which consists of maximal safe resection of the contrast-enhancing portion of the tumor followed by radiation therapy with concomitant adjuvant temozolomide (TMZ) remains 15 months. The tumor microenvironment (TME) is known to contain immune suppressive myeloid cells with minimal effector T cell infiltration. Stimulator of interferon...

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Literature Corpus work: b802bca8-294d-5e5f-9203-5e70be1fe30b
DOI: 10.12688/f1000research.125163.1

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