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Article

Targeting Phosphatase and Tensin Homolog Deleted on Chromosome 10q23.3 (PTEN) as a Potential Theragnostic Biomarker in Tumors.

Recent patents on anti-cancer drug discovery - 1 Jan 2026

Liu Ying, Li Tian, Zhang Lifen, He Shuhua, Hui Jialiang

Abstract excerpt

BACKGROUND: Immunotherapy and targeted therapy have been shown to be notably effective in tumor treatment; however, the mechanism of PTEN function in tumorigenesis, development, and immune response of tumors remains unclear. METHODS: We show that PTEN expression varies significantly in many types of tumors and affects the prognosis of patients with cancer using pan-cancer analysis. Patents were reviewed using the...

Read the complete abstract on PubMed

Topics

Humans
PTEN Phosphohydrolase
Biomarkers, Tumor
Neoplasms
Prognosis
Patents as Topic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Chromosomes, Human, Pair 10

Immunotherapy

Mutation

Animals

Lymphocytes, Tumor-Infiltrating

Gene Expression Regulation, Neoplastic

Source

Identifiers

PMID: 40396319
DOI: 10.2174/0115748928370540250508101925

Genes

PTEN
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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Targeting Phosphatase and Tensin Homolog Deleted on Chromosome 10q23.3 (PTEN) as a Potential Theragnostic Biomarker in Tumors.PMID 40396319Read ↗

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