Article
Primary mismatch repair deficient glioma, IDH-wildtype and H3-wildtype: A giant cell tumor with potential for long-term survival occurring at all ages.
Neuro-oncology - 1 Sept 2026
Suwala Abigail K, Friedel Dennis, Hinz Felix E, Mahlknecht Philipp D, Schinkewitsch Sophia, Rieder Mathias, Fernandez Nicholas R, Stengs Lucie, Chang Yuan, Ringel Amit, Haag Daniel, Pusch Stefan, Stichel Damian, Schrimpf Daniel, Kramm Christof M, Wesseling Pieter, Schweizer Leonille, Harter Patrick, Hartmann Christian, Capper David, Snuderl Matija, Boldt Henning, Brandner Sebastian, Dohmen Hildegard, Acker Till, Schittenhelm Jens, Hasselblatt Martin, Agardy Dennis, Bunse Theresa, Bunse Lukas, Korshunov Andrey, Herold-Mende Christel, Etminan Nima, Wick Wolfgang, Platten Michael, Das Anirban, Tabori Uri, Blattner-Johnson Mirjam, Sill Martin, Sturm Dominik, Pfister Stefan M, Jones David T W, Sahm Felix, von Deimling Andreas, Reuss David E
Abstract excerpt
BACKGROUND: Replication repair deficiency is associated with increased risk of developing malignant gliomas. The aim of this study was to investigate primary mismatch repair deficient gliomas (PMMRDGs), a group of IDH-wildtype and H3-wildtype gliomas that is enriched among patients with CMMRD and Lynch syndrome. METHODS: We investigated how PMMRDGs differ from other gliomas with respect to DNA methylation...
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- Humans