Article
Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies.
Genome biology - 8 Dec 2023
Voon Hsiao P J, Hii Linda, Garvie Andrew, Udugama Maheshi, Krug Brian, Russo Caterina, Chüeh Anderly C, Daly Roger J, Morey Alison, Bell Toby D M, Turner Stephen J, Rosenbluh Joseph, Daniel Paul, Firestein Ron, Mann Jeffrey R, Collas Philippe, Jabado Nada, Wong Lee H
Abstract excerpt
BACKGROUND: Point mutations in histone variant H3.3 (H3.3K27M, H3.3G34R) and the H3.3-specific ATRX/DAXX chaperone complex are frequent events in pediatric gliomas. These H3.3 point mutations affect many chromatin modifications but the exact oncogenic mechanisms are currently unclear. Histone H3.3 is known to localize to nuclear compartments known as promyelocytic leukemia (PML) nuclear bodies, which are...
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