Article
K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas.
Acta neuropathologica - 1 Sept 2012
Khuong-Quang Dong-Anh, Buczkowicz Pawel, Rakopoulos Patricia, Liu Xiao-Yang, Fontebasso Adam M, Bouffet Eric, Bartels Ute, Albrecht Steffen, Schwartzentruber Jeremy, Letourneau Louis, Bourgey Mathieu, Bourque Guillaume, Montpetit Alexandre, Bourret Genevieve, Lepage Pierre, Fleming Adam, Lichter Peter, Kool Marcel, von Deimling Andreas, Sturm Dominik, Korshunov Andrey, Faury Damien, Jones David T, Majewski Jacek, Pfister Stefan M, Jabado Nada, Hawkins Cynthia
Abstract excerpt
Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are devastating brain tumors with no effective therapy. Here, we investigated clinical and biological impacts of histone H3.3 mutations. Forty-two DIPGs were tested for H3.3 mutations. Wild-type versus mutated (K27M-H3.3) subgroups were compared for HIST1H3B, IDH, ATRX and TP53 mutations, copy number alterations and clinical outcome....
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