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Article

Hydroxymethylated cytosines are associated with elevated C to G transversion rates.

PLoS genetics - 1 Sept 2014

Supek Fran, Lehner Ben, Hajkova Petra, Warnecke Tobias

Abstract excerpt

It has long been known that methylated cytosines deaminate at higher rates than unmodified cytosines and constitute mutational hotspots in mammalian genomes. The repertoire of naturally occurring cytosine modifications, however, extends beyond 5-methylcytosine to include its oxidation derivatives, notably 5-hydroxymethylcytosine. The effects of these modifications on sequence evolution are unknown. Here, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25211471
DOI: 10.1371/journal.pgen.1004585
PMCID: PMC4161303

Genes

MBD4
MSH2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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