Article
DNA methylation and mutation.
Mutation research - 1 Jan 1993
Holliday R, Grigg G W
Abstract excerpt
5-Methylcytosine (5mC) in DNA is produced by post-synthetic modification of cytosine residues, and it occurs primarily in CpG doublets in the mammalian genome. 5mC is a mutable site, because it can undergo spontaneous deamination to thymine. There is a repair mechanism which specifically recognises G.T mispairs, and replaces thymine with cytosine. However, this repair is not fully efficient, because the 5mC-->T...
Topics
- 5-Methylcytosine
- Animals
- Base Composition
- Cytosine
- DNA
- DNA Repair
- Dinucleoside Phosphates
- Humans
- Methylation
- Mutation
- Neoplasms