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Article

5-Hydroxymethylcytosine (5hmC) at or near cancer mutation hot spots as potential targets for early cancer detection.

BMC research notes - 21 Apr 2022

Lu Michael J, Lu Yabin

Abstract excerpt

OBJECTIVE: Universal noninvasive genomic screening to detect cancer and/or fetal DNA in plasma at all stages of development is highly warranted. Since 5-hydroxymethylcytosine (5hmC) emerged as an intermediate metabolite in active DNA demethylation, there have been increasing efforts to elucidate its function as a stable modification of the genome. In the current study, we demonstrate that discrete 5hmC sites...

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Identifiers

PMID: 35449110
DOI: 10.1186/s13104-022-06028-w
PMCID: PMC9022237

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