Article
Pathogenic mitochondrial DNA variants are associated with response to anti-VEGF therapy in ovarian cancer PDX models.
Journal of experimental & clinical cancer research : CR - 19 Dec 2024
Boso Daniele, Piga Ilaria, Trento Chiara, Minuzzo Sonia, Angi Eleonora, Iommarini Luisa, Lazzarini Elisabetta, Caporali Leonardo, Fiorini Claudio, D'Angelo Luigi, De Luise Monica, Kurelac Ivana, Fassan Matteo, Porcelli Anna Maria, Navaglia Filippo, Billato Ilaria, Esposito Giovanni, Gasparre Giuseppe, Romualdi Chiara, Indraccolo Stefano
Abstract excerpt
BACKGROUND: Mitochondrial DNA (mtDNA) pathogenic variants have been reported in several solid tumors including ovarian cancer (OC), the most lethal gynecologic malignancy, and raised interest as they potentially induce mitochondrial dysfunction and rewiring of cellular metabolism. Despite advances in recent years, functional characterization of mtDNA variants in cancer and their possible modulation of drug...
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