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Article

Metastatic pattern of ovarian cancer delineated by tracing the evolution of mitochondrial DNA mutations.

Experimental & molecular medicine - 1 Jul 2023

Xu Zhiyang, Zhou Kaixiang, Wang Zhenni, Liu Yang, Wang Xingguo, Gao Tian, Xie Fanfan, Yuan Qing, Gu Xiwen, Liu Shujuan, Xing Jinliang

Abstract excerpt

Ovarian cancer (OC) is the most lethal gynecologic tumor and is characterized by a high rate of metastasis. Challenges in accurately delineating the metastatic pattern have greatly restricted the improvement of treatment in OC patients. An increasing number of studies have leveraged mitochondrial DNA (mtDNA) mutations as efficient lineage-tracing markers of tumor clonality. We applied multiregional sampling and...

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Identifiers

PMID: 37394583
DOI: 10.1038/s12276-023-01011-2
PMCID: PMC10393968

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