Article
Mutational profiling of mtDNA control region reveals tumor-specific evolutionary selection involved in mitochondrial dysfunction.
EBioMedicine - 1 Jun 2022
Ji Xiaoying, Guo Wenjie, Gu Xiwen, Guo Shanshan, Zhou Kaixiang, Su Liping, Yuan Qing, Liu Yang, Guo Xu, Huang Qichao, Xing Jinliang
Abstract excerpt
BACKGROUND: Mitochondrial DNA (mtDNA) mutations alter mitochondrial function in oxidative metabolism and play an important role in tumorigenesis. A series of studies have demonstrated that the mtDNA control region (mtCTR), which is essential for mtDNA replication and transcription, represents a mutational hotspot in human tumors. However, a comprehensive pan-cancer evolutionary pattern analysis of mtCTR mutations...
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