Article
The bug, the burden, and the biology: beyond host-centric phenotyping in sepsis.
The Journal of clinical investigation - 16 Mar 2026
Kitsios Georgios D, Baron Rebecca M
Abstract excerpt
For over a decade, sepsis phenotyping has identified hyperinflammatory and hypoinflammatory subphenotypes using host biomarkers and clinical variables, without factoring in contributions from infectious insults across patients. In this issue, Chanderraj and colleagues challenge this host-centric paradigm by demonstrating that pathogen characteristics independently contribute to sepsis subphenotypes. They reported...
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