Article
Pathogen characteristics are key determinants of distinct host response phenotypes of sepsis.
The Journal of clinical investigation - 16 Mar 2026
Chanderraj Rishi, Bartek Brian, Stringer Kathleen A, Tiba Mohamad H, Sjoding Michael W, He Ying, Nuppnau Mark, Bongers Kale S, Adame Mark D, Lou Sunny S, Kerschberger V Eric, Churpek Matthew M, Calfee Carolyn S, Tripathi Sandhya, Foster Debra M, Kellum John A, Dickson Robert P, Sinha Pratik
Abstract excerpt
BACKGROUNDSepsis encompasses considerable biological and clinical heterogeneity. Previously, 2 phenotypes ("hyperinflammatory" and "hypoinflammatory") have been consistently identified within sepsis via latent class analysis. These phenotypes differ in their biological features, clinical outcomes, and therapeutic responses to interventions. Prior studies of sepsis heterogeneity have focused primarily on the host...
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