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Article

Meta-regression of genome-wide association studies to estimate age-varying genetic effects.

European journal of epidemiology - 1 Mar 2024

Pagoni Panagiota, Higgins Julian P T, Lawlor Deborah A, Stergiakouli Evie, Warrington Nicole M, Morris Tim T, Tilling Kate

Abstract excerpt

Fixed-effect meta-analysis has been used to summarize genetic effects on a phenotype across multiple Genome-Wide Association Studies (GWAS) assuming a common underlying genetic effect. Genetic effects may vary with age (or other characteristics), and not allowing for this in a GWAS might lead to bias. Meta-regression models between study heterogeneity and allows effect modification of the genetic effects to be...

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Identifiers

PMID: 38183607
DOI: 10.1007/s10654-023-01086-1
PMCID: PMC10995067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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