Article
Genotype-covariate interaction effects and the heritability of adult body mass index.
Nature genetics - 1 Aug 2017
Robinson Matthew R, English Geoffrey, Moser Gerhard, Lloyd-Jones Luke R, Triplett Marcus A, Zhu Zhihong, Nolte Ilja M, van Vliet-Ostaptchouk Jana V, Snieder Harold, Esko Tonu, Milani Lili, Mägi Reedik, Metspalu Andres, Magnusson Patrik K E, Pedersen Nancy L, Ingelsson Erik, Johannesson Magnus, Yang Jian, Cesarini David, Visscher Peter M
Abstract excerpt
Obesity is a worldwide epidemic, with major health and economic costs. Here we estimate heritability for body mass index (BMI) in 172,000 sibling pairs and 150,832 unrelated individuals and explore the contribution of genotype-covariate interaction effects at common SNP loci. We find evidence for genotype-age interaction (likelihood ratio test (LRT) = 73.58, degrees of freedom (df) = 1, P = 4.83 × 10-18), which...
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