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Article

An evaluation of age-varying genetic effects underlying body-mass index and blood pressure in the UK Biobank.

PLoS genetics - 1 Mar 2026

Leyden Genevieve M, Pagoni Panagiota, Power Grace M, Carslake David, Richardson Tom G, Tilling Kate, Hemani Gibran, Davey Smith George, Sanderson Eleanor

Abstract excerpt

Genome-wide association studies (GWAS) are conventionally conducted in cohorts spanning a wide age-range. These studies typically assume that genetic associations are constant across different ages. Some traits, however, may have age-varying genetic associations. This has implications for the interpretation of genetic effects derived in downstream applications, such as Mendelian randomization (MR) analyses. In...

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Identifiers

PMID: 41860901
DOI: 10.1371/journal.pgen.1012080
PMCID: PMC13029756

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