Article

A framework for conducting time-varying genome-wide association studies: An application to body mass index across childhood in six multiethnic cohorts

2024-03-16

Abstract excerpt

Genetic effects on changes in human traits over time are understudied and may have important pathophysiological impact. We propose a framework that enables data quality control, implements mixed models to evaluate trajectories of change in traits, and estimates phenotypes to identify age-varying genetic effects in genome-wide association studies (GWASs). Using childhood body mass index (BMI) as an example, we incl...

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Literature Corpus work: 20d3828d-2a80-5341-b977-19aa54a70163
DOI: 10.1101/2024.03.13.24304263

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