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An Evaluation of Age-varying Genetic Effects underlying Body-mass Index and Blood Pressure in the UK Biobank

2025-12-17

Abstract excerpt

Genome-wide association studies (GWAS) are conventionally conducted in cohorts spanning a wide age-range. These studies typically assume that genetic associations are constant across different ages. Some traits, however, may have age-varying genetic associations. This has implications for the interpretation of genetic effects derived in downstream applications, such as Mendelian randomization (MR) analyses. In thi...

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Literature Corpus work
cdd70fb4-c843-5792-a7a2-7f9fc8005f6c
DOI
10.64898/2025.12.16.25342301
Open publication

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An Evaluation of Age-varying Genetic Effects underlying Body-mass Index and Blood Pressure in the UK BiobankDOI 10.64898/2025.12.16.25342301
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