Article
Gene-by-age effects on BMI from birth to adulthood: the Fels Longitudinal Study.
Obesity (Silver Spring, Md.) - 1 Mar 2014
Choh Audrey C, Lee Miryoung, Kent Jack W, Diego Vincent P, Johnson William, Curran Joanne E, Dyer Thomas D, Bellis Claire, Blangero John, Siervogel Roger M, Towne Bradford, Demerath Ellen W, Czerwinski Stefan A
Abstract excerpt
OBJECTIVES: Genome wide association studies have shown 32 loci to influence BMI in European-American adults but replication in other studies is inconsistent and may be attributed to gene-by-age effects. The aims of this study were to determine if the influence of the summed risk score of these 32 loci (GRS) on BMI differed across age from birth to 40 years, and to determine if additive genetic effects other than...
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