Article
On the replication of genetic associations: timing can be everything!
American journal of human genetics - 1 Apr 2008
Lasky-Su Jessica, Lyon Helen N, Emilsson Valur, Heid Iris M, Molony Cliona, Raby Benjamin A, Lazarus Ross, Klanderman Barbara, Soto-Quiros Manuel E, Avila Lydiana, Silverman Edwin K, Thorleifsson Gudmar, Thorsteinsdottir Unnur, Kronenberg Florian, Vollmert Caren, Illig Thomas, Fox Caroline S, Levy Daniel, Laird Nan, Ding Xiao, McQueen Matt B, Butler Johannah, Ardlie Kristin, Papoutsakis Constantina, Dedoussis George, O'Donnell Christopher J, Wichmann H-Erich, Celedón Juan C, Schadt Eric, Hirschhorn Joel, Weiss Scott T, Stefansson Kari, Lange Christoph
Abstract excerpt
The failure of researchers to replicate genetic-association findings is most commonly attributed to insufficient statistical power, population stratification, or various forms of between-study heterogeneity or environmental influences.(1) Here, we illustrate another potential cause for nonreplications that has so far not received much attention in the literature. We illustrate that the strength of a genetic...
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