Article
Exploring the Major Sources and Extent of Heterogeneity in a Genome-Wide Association Meta-Analysis.
Annals of human genetics - 1 Mar 2016
Pei Yu-Fang, Tian Qing, Zhang Lei, Deng Hong-Wen
Abstract excerpt
Genome-wide association (GWA) meta-analysis has become a popular approach for discovering genetic variants responsible for complex diseases. The between-study heterogeneity effect is a severe issue that may complicate the interpretation of results. Aiming to improve the interpretation of meta-analysis results, we empirically explored the extent and source of heterogeneity effect. We analyzed a previously reported...
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