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Article

The role of environmental heterogeneity in meta-analysis of gene-environment interactions with quantitative traits.

Genetic epidemiology - 1 Jul 2014

Li Shi, Mukherjee Bhramar, Taylor Jeremy M G, Rice Kenneth M, Wen Xiaoquan, Rice John D, Stringham Heather M, Boehnke Michael

Abstract excerpt

With challenges in data harmonization and environmental heterogeneity across various data sources, meta-analysis of gene-environment interaction studies can often involve subtle statistical issues. In this paper, we study the effect of environmental covariate heterogeneity (within and between cohorts) on two approaches for fixed-effect meta-analysis: the standard inverse-variance weighted meta-analysis and a...

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Identifiers

PMID: 24801060
DOI: 10.1002/gepi.21810
PMCID: PMC4108593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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