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Article

Characterization of integrated hepatitis B virus DNA harboring pre-S mutations in hepatocellular carcinoma patients with ground glass hepatocytes.

Journal of medical virology - 1 Jan 2024

Su Yih-Ping, Lin Selena Y, Su Ih-Jen, Kao Yu-Lan, Shen Shih-Chun, Earl Joshua P, Ehrlich Garth D, Chen Cheng-Yi, Huang Wenya, Su Ying-Hsiu, Tsai Hung-Wen

Abstract excerpt

Ground glass hepatocytes (GGHs) have been associated with hepatocellular carcinoma (HCC) recurrence and poor prognosis. We previously demonstrated that pre-S expression in some GGHs is resistant to current hepatitis B virus (HBV) antiviral therapies. This study aimed to investigate whether integrated HBV DNA (iDNA) is the primary HBV DNA species responsible for sustained pre-S expression in GGH after effective...

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Share to Antiviral Agents
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Viral

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Share to Liver Neoplasms

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Source

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Identifiers

PMID: 38180275
DOI: 10.1002/jmv.29348
PMCID: PMC10802935

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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