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The emerging role of hepatitis B virus Pre-S2 deletion mutant proteins in HBV tumorigenesis

14 Oct 2014

Abstract excerpt

Chronic hepatitis B virus (HBV) infection can cause hepatocellular carcinoma (HCC). Several hypotheses have been proposed to explain the mechanisms of HBV tumorigenesis, including inflammation and liver regeneration associated with cytotoxic immune injuries and transcriptional activators of mutant HBV gene products. The mutant viral oncoprotein-driven tumorigenesis is prevailed at the advanced stage or...

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PMID: 25316153
DOI: 10.1186/s12929-014-0098-7

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