Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ground glass hepatocytes contain pre-S mutants and represent preneoplastic lesions in chronic hepatitis B virus infection.

Journal of gastroenterology and hepatology - 1 Aug 2008

Su Ih-Jen, Wang Hui-Ching, Wu Han-Chieh, Huang Wen-Ya

Abstract excerpt

The discovery of "ground glass" hepatocytes (GGH) that contain hepatitis B virus (HBV) surface antigens by Hadziyannis and Popper in 1973 represents a historical landmark in the pathology of chronic HBV infection. Different types of GGH have been correlated to the expression patterns of surface/core antigens and the stages of virus replication. The original two types (designated types I & II) of GGH were found to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis B, Chronic
Share to Hepatitis B Virus Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatocytes

Share to Liver Neoplasms

Share to Mutation

Share to Protein Precursors

Share to Protein S

Source

Identifiers

PMID: 18505413
DOI: 10.1111/j.1440-1746.2008.05348.x

Genes

GGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ground glass hepatocytes contain pre-S mutants and represent preneoplastic lesions in chronic hepatitis B virus infection.PMID 18505413Read ↗

Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stress.Semantic proximity Read ↗

Hepatitis B virus pre-S mutants, endoplasmic reticulum stress and hepatocarcinogenesis.Semantic proximity Read ↗

Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage.Semantic proximity Read ↗

The emerging role of hepatitis B virus Pre-S2 deletion mutant proteins in HBV tumorigenesisSemantic proximity Read ↗

Pre-S2 Mutant-Induced Mammalian Target of Rapamycin Signal Pathways as Potential Therapeutic Targets for Hepatitis B Virus-Associated Hepatocellular CarcinomaSemantic proximity Read ↗

Hepatitis B virus pre-S2 mutant large surface protein inhibits DNA double-strand break repair and leads to genome instability in hepatocarcinogenesis.Semantic proximity Read ↗

Hepatocellular carcinoma and hepatitis B surface protein.Semantic proximity Read ↗

Characterization of integrated hepatitis B virus DNA harboring pre-S mutations in hepatocellular carcinoma patients with ground glass hepatocytes.Semantic proximity Read ↗

Hepatitis B Virus Pre-S Mutants as Biomarkers and Targets for the Development and Recurrence of Hepatocellular Carcinoma.Semantic proximity Read ↗

Hepatitis B Virus Pre-S Gene Deletions and Pre-S Deleted Proteins: Clinical and Molecular Implications in Hepatocellular CarcinomaSemantic proximity Read ↗

A clustered ground-glass hepatocyte pattern represents a new prognostic marker for the recurrence of hepatocellular carcinoma after surgery.Semantic proximity Read ↗

Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.