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Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage.

Carcinogenesis - 1 Oct 2004

Hsieh Yi-Hsuan, Su Ih-Jen, Wang Hui-Ching, Chang Wen-Wei, Lei Huan-Yao, Lai Ming-Derg, Chang Wen-Tsan, Huang Wenya

Abstract excerpt

Ground glass hepatocytes (GGHs) are the historic hallmarks for the hepatocytes in the late and non-replicative stages of hepatitis B virus (HBV) infection. We have identified type I and type II GGHs that contain two mutant types of large HBV surface antigens (HBsAg) with deletions over the pre-S1 and pre-S2 regions, respectively. These pre-S mutant HBVsAg accumulate in endoplasmic reticulum (ER), resulting in...

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PMID: 15180947
DOI: 10.1093/carcin/bgh207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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