Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepatitis B virus pre-S2 mutant large surface protein inhibits DNA double-strand break repair and leads to genome instability in hepatocarcinogenesis.

The Journal of pathology - 1 Jul 2015

Hsieh Yi-Hsuan, Chang Yu-Ying, Su Ih-Jen, Yen Chia-Jui, Liu Yi-Ru, Liu Ren-Jei, Hsieh Wen-Chuan, Tsai Hung-Wen, Wang Lily Hui-Ching, Huang Wenya

Abstract excerpt

Although hepatitis B virus (HBV) has been established to cause hepatocellular carcinoma (HCC), the exact mechanism remains to be clarified. Type II ground glass hepatocytes (GGHs) harbouring the HBV pre-S2 mutant large surface protein (LHBS) have been recognized as a morphologically distinct hallmark of HCC in the advanced stages of chronic HBV infection. Considering its preneoplastic nature, we hypothesized that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Viral
Share to Comparative Genomic Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

Share to Genomic Instability

Share to Hepatitis B Surface Antigens

Share to Hepatocytes

Share to Protein Precursors

Share to Viral Envelope Proteins

Source

Identifiers

PMID: 25775999
DOI: 10.1002/path.4531

Genes

GGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepatitis B virus pre-S2 mutant large surface protein inhibits DNA double-strand break repair and leads to genome instability in hepatocarcinogenesis.PMID 25775999Read ↗

The emerging role of hepatitis B virus Pre-S2 deletion mutant proteins in HBV tumorigenesisSemantic proximity Read ↗

Ground glass hepatocytes contain pre-S mutants and represent preneoplastic lesions in chronic hepatitis B virus infection.Semantic proximity Read ↗

Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage.Semantic proximity Read ↗

Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stress.Semantic proximity Read ↗

Hepatitis B virus pre-S mutants, endoplasmic reticulum stress and hepatocarcinogenesis.Semantic proximity Read ↗

Pre-S2 Mutant-Induced Mammalian Target of Rapamycin Signal Pathways as Potential Therapeutic Targets for Hepatitis B Virus-Associated Hepatocellular CarcinomaSemantic proximity Read ↗

Hepatitis B virus pre-S2 mutant surface antigen induces degradation of cyclin-dependent kinase inhibitor p27Kip1 through c-Jun activation domain-binding protein 1.Semantic proximity Read ↗

Aberrant cyclin A expression and centrosome overduplication induced by hepatitis B virus pre-S2 mutants and its implication in hepatocarcinogenesis.Semantic proximity Read ↗

Genomic instability caused by hepatitis B virus: into the hepatoma inferno.Semantic proximity Read ↗

Hepatitis B Virus Pre-S Gene Deletions and Pre-S Deleted Proteins: Clinical and Molecular Implications in Hepatocellular CarcinomaSemantic proximity Read ↗

Epigenetic Regulation of MicroRNA Expression by Hepatitis B Virus Pre-S2 Mutant Promotes Hepatocellular Carcinoma Tumorigenesis.Semantic proximity Read ↗

Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.