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Article

TREX2 deficiency suppresses spontaneous and genotoxin-associated mutagenesis.

Cell reports - 23 Jan 2024

Marple Teresa, Son Mi Young, Cheng Xiaodong, Ko Jun Ho, Sung Patrick, Hasty Paul

Abstract excerpt

TREX2, a 3'-5' exonuclease, is a part of the DNA damage tolerance (DDT) pathway that stabilizes replication forks (RFs) by ubiquitinating PCNA along with the ubiquitin E3 ligase RAD18 and other DDT factors. Mismatch repair (MMR) corrects DNA polymerase errors, including base mismatches and slippage. Here we demonstrate that TREX2 deletion reduces mutations in cells upon exposure to genotoxins, including those...

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Identifiers

PMID: 38175749
DOI: 10.1016/j.celrep.2023.113637
PMCID: PMC10883656

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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