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Article

Diverse roles of RAD18 and Y-family DNA polymerases in tumorigenesis

3 Apr 2018

Abstract excerpt

Mutagenesis is a hallmark and enabling characteristic of cancer cells. The E3 ubiquitin ligase RAD18 and its downstream effectors, the 'Y-family' Trans-Lesion Synthesis (TLS) DNA polymerases, confer DNA damage tolerance at the expense of DNA replication fidelity. Thus, RAD18 and TLS polymerases are attractive candidate mediators of mutagenesis and carcinogenesis. The skin cancer-propensity disorder xeroderma...

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Identifiers

PMID: 29683380
DOI: 10.1080/15384101.2018.1456296

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