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Article

T Cells Produce IFN-α in the TREX1 D18N Model of Lupus-like Autoimmunity

11 Dec 2019

Abstract excerpt

Autoimmunity can result when cells fail to properly dispose of DNA. Mutations in the three-prime repair exonuclease 1 (TREX1) cause a spectrum of human autoimmune diseases resembling systemic lupus erythematosus. The cytosolic dsDNA sensor, cyclic GMP-AMP synthase (cGAS), and the stimulator of IFN genes (STING) are required for pathogenesis, but specific cells in which DNA sensing and subsequent type I IFN...

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PMID: 31826941
DOI: 10.4049/jimmunol.1900220

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