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Article

TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced Replication Fork Defects in Cells Expressing RAD51K133A.

Cell reports - 22 Dec 2020

Ko Jun Ho, Son Mi Young, Zhou Qing, Molnarova Lucia, Song Lambert, Mlcouskova Jarmila, Jekabsons Atis, Montagna Cristina, Krejci Lumir, Hasty Paul

Abstract excerpt

DNA damage tolerance (DDT) and homologous recombination (HR) stabilize replication forks (RFs). RAD18/UBC13/three prime repair exonuclease 2 (TREX2)-mediated proliferating cell nuclear antigen (PCNA) ubiquitination is central to DDT, an error-prone lesion bypass pathway. RAD51 is the recombinase for HR. The RAD51 K133A mutation increased spontaneous mutations and stress-induced RF stalls and nascent strand...

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Identifiers

PMID: 33357432
DOI: 10.1016/j.celrep.2020.108543
PMCID: PMC7896812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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