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Article

Increased Susceptibility to Skin Carcinogenesis in TREX2 Knockout Mice.

Cancer research - 15 Aug 2009

Parra David, Manils Joan, Castellana Bàrbara, Viña-Vilaseca Arnau, Morán-Salvador Eva, Vázquez-Villoldo Nuria, Tarancón Gemma, Borràs Miquel, Sancho Sara, Benito Carmen, Ortega Sagrario, Soler Concepció

Abstract excerpt

TREX2 is a proofreading 3'-5' exonuclease that can be involved in genome maintenance; however, its biological role remains undefined. To better understand the function and physiologic relevance of TREX2, we generated mice deficient in TREX2 by targeted disruption of its unique coding exon. The knockout mice are viable and do not show relevant differences in growth, survival, lymphocyte development, or spontaneous...

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Identifiers

PMID: 19654293
DOI: 10.1158/0008-5472.CAN-09-1208

Genes

TREX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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