Article
IFT57 stabilizes the assembled intraflagellar transport complex and mediates transport of motility-related flagellar cargo.
Journal of cell science - 1 Mar 2017
Jiang Xue, Hernandez Daniel, Hernandez Catherine, Ding Zhaolan, Nan Beiyan, Aufderheide Karl, Qin Hongmin
Abstract excerpt
Intraflagellar transport (IFT) is essential for the assembly and maintenance of flagella and cilia. Recent biochemical studies have shown that IFT complex B (IFT-B) is comprised of two subcomplexes, IFT-B1 and IFT-B2. The IFT-B2 subunit IFT57 lies at the interface between IFT-B1 and IFT-B2. Here, using a Chlamydomonasreinhardtii mutant for IFT57, we tested whether IFT57 is required for IFT-B complex assembly by...
Topics
- 5' Untranslated Regions
- Adaptor Proteins, Signal Transducing
- Autotrophic Processes
- Axoneme
- Biological Transport
- Chlamydomonas reinhardtii
- Dyneins
- Flagella
- Movement
- Mutagenesis, Insertional
- Mutation
- Plant Proteins
- Protein Stability
- Protein Transport