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Article

Role for the IFT-A Complex in Selective Transport to the Primary Cilium.

Cell reports - 1 Nov 2016

Fu Wenxiang, Wang Lei, Kim Sehyun, Li Ji, Dynlacht Brian David

Abstract excerpt

Intraflagellar transport sub-complex A (IFT-A) is known to regulate retrograde IFT in the cilium. To rigorously assess its other possible roles, we knocked out an IFT-A subunit, IFT121/WDR35, in mammalian cells and screened the localization of more than 50 proteins. We found that Wdr35 regulates cilium assembly by selectively regulating transport of distinct cargoes. Beyond its role in retrograde transport, we...

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Identifiers

PMID: 27806291
DOI: 10.1016/j.celrep.2016.10.018
PMCID: PMC5123888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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