Evaluation of mutations on O6-methylguanine methyl transferase structure and its interactions: molecular dynamics simulation study.

doi:10.1080/07391102.2023.2300133

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Article

Evaluation of mutations on O6-methylguanine methyl transferase structure and its interactions: molecular dynamics simulation study.

Journal of biomolecular structure & dynamics - 1 May 2025

Gharouni Marzieh, Mosaddeghi Hamid

Abstract excerpt

O6-methylguanine DNA methyl transferase (MGMT) is a significant vehicle for the cellular clearance of alkyl lesions, particularly the methyl group of the O-6 and O-4 positions of guanine and thymine, respectively. Many publications have studied the correlation between polymorphisms in MGMT and susceptibility to various cancers. In the present study, we investigated the consequence of L84F, common...

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Topics

Molecular Dynamics Simulation
Mutation
Humans
Protein Binding
Proliferating Cell Nuclear Antigen
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

O(6)-Methylguanine-DNA Methyltransferase

DNA Modification Methylases

DNA Repair Enzymes

Protein Conformation

DNA

Thermodynamics

Tumor Suppressor Proteins

Source

Open in PubMed

Identifiers

PMID: 38166600
DOI: 10.1080/07391102.2023.2300133

Genes

MGMT
PCNA

Provenance

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