Article
Deciphering the effect of mutations in MMAA protein causing methylmalonic acidemia-A computational approach.
Advances in protein chemistry and structural biology - 1 Jan 2022
Madhana Priya N, Udhaya Kumar S, Thirumal Kumar D, Magesh R, Siva R, Gnanasambandan R, George Priya Doss C
Abstract excerpt
Methylmalonic acidemia (MMA) is a rare genetic disorder affecting multiple body systems. We aimed to investigate the pathogenic mutations in MMAA that are associated with isolated methylmalonic acidemia to identify the structural behavior of MMAA upon mutation. The algorithms such as PredictSNP, iStable, ConSurf, and Align GVGD were employed to analyze the consequence of the mutations. Molecular docking was...
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