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Structural and functional analysis of disease-associated mutations in GOT1 gene: An in silico study.

Computers in biology and medicine - 1 Sept 2021

Saxena Sidharth, Achyuth B Sai, Murthy T P Krishna, Chandramohan Vivek, Yadav Arvind Kumar, Singh Tiratha Raj

Abstract excerpt

Disease-associated single nucleotide polymorphisms (SNPs) alter the natural functioning and the structure of proteins. Glutamic-oxaloacetic transaminase 1 (GOT1) is a gene associated with multiple cancers and neurodegenerative diseases which codes for aspartate aminotransferase. The present study involved a comprehensive in-silico analysis of the disease-associated SNPs of human GOT1. Four highly deleterious...

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PMID: 34352456
DOI: 10.1016/j.compbiomed.2021.104695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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