Article

Molecular dynamics simulations reveal the impact of NUTD15 variants in structural conformation and dynamics

2022-10-23

Abstract excerpt

NUDT15 or MTH2 is a member of NUDIX protein family that catalyze the hydrolysis of nucleotides and deoxynucleotides, including thioguanine analogues. NUTD15 has been reported as a DNA sanitizer in humans, and more recent studies have proved that genomic variants are related to a poor prognosis in inmoplastic and immunologic diseases with thioguanines. Despite of this, the role of NUTD15 in physiology and molecular...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 68625c0f-8882-5f99-a872-51d49f01bef3
DOI: 10.1101/2022.10.23.513377

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular dynamics simulations reveal the impact of NUTD15 variants in structural conformation and dynamicsDOI 10.1101/2022.10.23.513377Read

Molecular dynamics simulations reveal the impact of NUDT15 R139C and R139H variants in structural conformation and dynamics.Semantic proximity Read

Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.Semantic proximity Read

NUDT15: A bench to bedside success story.Semantic proximity Read

Massive parallel variant characterization identifies <i>NUDT15</i> alleles associated with thiopurine toxicitySemantic proximity Read

The T1150A cancer mutant of the protein lysine dimethyltransferase NSD2 can introduce H3K36 trimethylation.Semantic proximity Read

Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity.Semantic proximity Read

Computational Analysis of nsSNPs of ADA Gene in Severe Combined Immunodeficiency Using Molecular Modeling and Dynamics Simulation.Semantic proximity Read

Classification of VUS and unclassified variants in BRCA1 BRCT repeats by molecular dynamics simulationSemantic proximity Read

Investigating the Effects of Amino Acid Variations in Human Menin.Semantic proximity Read

Insight into TPMT(∗)23 mutation mis-folding using molecular dynamics simulation and protein structure analysis.Semantic proximity Read

Effects of single nucleotide polymorphisms on human N-acetyltransferase 2 structure and dynamics by molecular dynamics simulation.Semantic proximity Read

Structural genomics approach to investigate deleterious impact of nsSNPs in conserved telomere maintenance component 1.Semantic proximity Read