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Article

A bioinformatics approach to the identification of novel deleterious mutations of human TPMT through validated screening and molecular dynamics.

Scientific reports - 7 Nov 2022

Saxena Sidharth, Krishna Murthy T P, Chandrashekhar C R, Patil Lavan S, Aditya Abhinav, Shukla Rohit, Yadav Arvind Kumar, Singh Tiratha Raj, Samantaray Mahesh, Ramaswamy Amutha

Abstract excerpt

Polymorphisms of Thiopurine S-methyltransferase (TPMT) are known to be associated with leukemia, inflammatory bowel diseases, and more. The objective of the present study was to identify novel deleterious missense SNPs of TPMT through a comprehensive in silico protocol. The initial SNP screening protocol used to identify deleterious SNPs from the pool of all TPMT SNPs in the dbSNP database yielded an accuracy of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36344599
DOI: 10.1038/s41598-022-23488-z
PMCID: PMC9640560

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