Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conformational flexibility and rotational binding shifts in W104C mutant MECP2-DNA complexes: A molecular simulation study.

Biochemical and biophysical research communications - 8 Sept 2025

Saha Mowmita, Paul Ishani, Ray Soumyadeep, Roy Alankar, Pyne Soumili, Ray Sujay

Abstract excerpt

Methyl-CpG-binding proteins are crucial epigenetic regulators associated with inborn genetic and neurodevelopmental disorders such as Rett Syndrome, Autism Spectrum Disorder, and Angelman Syndrome, as well as various malignancies, including colorectal, prostate, brain, breast, and endometrial cancers. The proteins that belong to Methyl Binding Domain (MBD) superfamily, have eleven members: SETDB1, SETDB2, MECP2,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methyl-CpG-Binding Protein 2

Share to Molecular Docking Simulation

Share to Molecular Dynamics Simulation

Share to Protein Binding

Share to Protein Conformation

Share to Rotation

Source

Identifiers

PMID: 40684532
DOI: 10.1016/j.bbrc.2025.152261

Genes

MECP2
BAZ2A
BAZ2B
BDNF
MBD1
SETDB1
SETDB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conformational flexibility and rotational binding shifts in W104C mutant MECP2-DNA complexes: A molecular simulation study.PMID 40684532Read ↗

Quantitative investigation of the effects of DNA modifications and protein mutations on MeCP2-MBD-DNA interactions.Semantic proximity Read ↗

Methyl-CpG Binding Protein 2 Reads Histone Methylation via an Aromatic Cage to Regulate Gene Expression and Chromatin AssociationSemantic proximity Read ↗

Molecular Context-Dependent Effects Induced by Rett Syndrome-Associated Mutations in MeCP2.Semantic proximity Read ↗

Structural, Dynamical, and Energetical Consequences of Rett Syndrome Mutation R133C in MeCP2.Semantic proximity Read ↗

Influence of the disordered domain structure of MeCP2 on its structural stability and dsDNA interaction.Semantic proximity Read ↗

Impact of Rett Syndrome Mutations on MeCP2 MBD StabilitySemantic proximity Read ↗

MECP2 MBD-ID Module: A Unified DNA/RNA Binding Interface Disrupted in Rett SyndromeSemantic proximity Read ↗

Structural dynamics of non-synonymous SNPs of histone methyltransferase EZH2 involved in Weaver SyndromeSemantic proximity Read ↗

A/T Run Geometry of B-form DNA Is Independent of Bound Methyl-CpG Binding Domain, Cytosine Methylation and Flanking Sequence.Semantic proximity Read ↗

Polymorphisms and disease: hotspots of inactivation in methyltransferases.Semantic proximity Read ↗

From Function to Phenotype: Impaired DNA Binding and Clustering Correlates with Clinical Severity in Males with Missense Mutations in MECP2.Semantic proximity Read ↗

Phylogenetic Profiling and Disordered Region Assessment of MECP2, CDKL5, and FOXG1 to Reveal Strategies for Rett Syndrome TreatmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.