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Article

Insight into TPMT(∗)23 mutation mis-folding using molecular dynamics simulation and protein structure analysis.

Journal of biomolecular structure & dynamics - 1 Oct 2013

Larif Sofiene, Ben Salem Chaker, Soua Zohra, Hmouda Houssem, Bouraoui Kamel

Abstract excerpt

Thiopurine S-methyltransferase (TPMT) is an important enzyme that metabolizes thiopurine drugs. This enzyme exhibits a large number of interindividual polymorphism. TPMT(∗)23 polymorphism has been reported in a few cases in the world in co-dominance with TPMT(∗)3A. The phenotype has been reported to affect enzyme activity in vivo and in vitro. Its underlying structural basis is not clarified yet. In our study,...

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Share to TPMT gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Protein Conformation

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Source

Identifiers

PMID: 23025308
DOI: 10.1080/07391102.2012.721495

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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